Geckos are a symbol of change such as transformation, death and rebirth. Spiritually and symbolically geckos mean much the same from one culture to another and although superstitions can vary, geckos often have profound, mystical and important rolls to play in various indigenous societies. Because they are a twilight and night creature their role is that of the dream keepers and shapeshifters.

The gecko is believed to be an ancestral spirit by many Pacific peoples. It is the "grand totem" of the people of New Caledonia.

The gecko lizard is one of the few reptiles that have a voice and in Hawaii the Gecko's chirp is often taken as an affirmation of spiritual significance. From Hawaii to the Zuni tribe of New Mexico, the Gecko is a symbol of good luck.